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|Section2= |Section3= }} Grubbs' Catalysts are a series of transition metal carbene complexes used as catalysts for olefin metathesis. They are named after Robert H. Grubbs, the chemist who first synthesized them. There are two generations of the catalyst, as shown on the right.〔Grubbs, R.H.; Trnka, T.M.: (Ruthenium-Catalyzed Olefin Metathesis ) in "Ruthenium in Organic Synthesis" (S.-I. Murahashi, Ed.), Wiley-VCH, Germany, 2004.〕 In contrast to other olefin metathesis catalysts, Grubbs' catalysts tolerate other functional groups in the alkene, are air-tolerant and are compatible with a wide range of solvents.〔 〕 For these reasons, Grubbs' catalysts have become popular in synthetic organic chemistry. ==First generation catalyst== The first well-defined ruthenium catalyst for olefin metathesis was discovered in 1992. It was prepared from RuCl2(PPh3)4 and diphenylcyclopropene. This initial ruthenium catalyst was followed in 1995 by what is now known as the first generation Grubbs catalyst. It is easily synthesized from RuCl2(PPh3)3, phenyldiazomethane, and tricyclohexylphosphine in a one-pot synthesis. The first generation Grubbs catalyst, while largely replaced by the second generation catalyst in usage, was not only the first catalyst to be developed other than those developed by Richard R. Schrock (Schrock carbenes), but is also important as a precursor to all other Grubbs-type catalysts. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Grubbs' catalyst」の詳細全文を読む スポンサード リンク
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